Six-letter word: outer letter pairs swapped, middle pair replaced by opposite letters

The same question, asked 2 times: 13 Sep 2024 S2*, 18 Sep 2024 S2. Every wording below, oldest first.

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Question 1
13 Sep 2024 S2
5 $Select the option that is related to the fifth term in the same way as the second term is related to the first term and the fourth term is related to the third term. READER : ERZWRE :: SERIAL : ESIRLA :: JINGLE : ?$
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Question 2
18 Sep 2024 S2
19 $Select the option that is related to the fifth term in the same way as the second term is related to the first term and the fourth term is related to the third term. CARBON : ACIYNO :: DAMAGE : ADNZEG :: MARGIN : ?$
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Question 1