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CBSE Class 12 Biology 2025 question paper (57/1)

Maximum marks 70 · Time 3 hours · 3 sets

Try each question first, then open its model answer. Where the paper offers a choice, both questions are shown with OR between them.

Section A

1 mark each

  1. Q.11 mark
    A man whose father was colour-blind marries a woman who had a colour-blind mother and normal father. What percentage of male children of this couple will be colour-blind ?

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  2. Q.21 mark
    GEAC stands for

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  3. Q.31 mark
    Match the items in Column-A with that of Column-B :
    Column-AColumn-B
    (i) Lady bird beetle(a) Methanobacterium
    (ii) Mycorrhiza(b) Trichoderma
    (iii) Biological control(c) Aphids
    (iv) Biogas(d) Glomus
    Choose the option that matches the items of Column A with that of B correctly :

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  4. Q.41 mark
    The process of mineralization by microorganisms help in the release of :

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  5. Q.51 mark
    Transplantation of tissues/organs to some patients often fails due to rejection of such tissues/organs by the body of the patient. Which type of immune response is responsible for such rejections ?

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  6. Q.61 mark
    Match the following items of Column-I with that of Column-II :
    Column-IColumn-II
    (a) Trophoblast(i) Embedding of blastocyst in the endometrium
    (b) Implantation(ii) Group of cells that would differentiate as embryo
    (c) Inner cell mass(iii) Embryo with 8-16 blastomeres
    (d) Morula(iv) Outer layer of blastocyst
    Choose the option that matches Column-I with Column-II correctly.

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  7. Q.71 mark
    The diagram given below shows labelling of four parts of a dicot embryo during its development as P, Q, R and S. Choose the option that indicates correct labelling of 'P', 'Q', 'R' and 'S' of embryo in different stages of its development :

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  8. Q.81 mark
    Amplification of gene of interest by using DNA polymerase may go upto

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  9. Q.91 mark
    The sequence of nitrogenous bases in a segment of a coding strand of DNA is 5' – AATGCTAGGCAC – 3'. Choose the option that shows the correct sequence of nitrogenous bases in the mRNA transcribed by the DNA.

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  10. Q.101 mark
    How many pollen grains and ovules are likely to be formed in the anther and the ovary of an angiosperm bearing 50 microspore mother cells and 50 megaspore mother cells respectively ?

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  11. Q.111 mark
    Evolution of modern man involves the following man-like primates. Choose the correct series of human evolution.

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  12. Q.121 mark
    RNA interference (RNAi) helps in making tobacco-plant resistant to a nematode (Meloidegyne incognitia) Choose the correct option that shows how RNAi is achieved :

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  13. For Question numbers 13 to 16, two statements are given – one labelled as Assertion (A) and the other labelled as Reason (R). Answer these questions by selecting the appropriate option given below :
    Q.131 mark
    Assertion (A) : Saheli is the World's first non-steroidal oral contraceptive pill. Reason (R) : It has been developed by National Institute of Immunology, New Delhi.

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  14. Q.141 mark
    Assertion (A) : One of the property of genetic code is degeneracy. Reason (R) : Some amino acids can be coded by more than one codon.

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  15. Q.151 mark
    Assertion (A) : A bioreactor provides the optimal conditions for achieving the desired product by providing optimum growth conditions. Reason (R) : The most commonly used bioreactors are of stirring type.

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  16. Q.161 mark
    Assertion (A) : When the two genes in a dihybrid cross are situated on the same chromosome, the proportion of parental gene combinations is much higher than non-parental type. Reason (R) : Higher parental gene combinations can be attributed to crossing over between two genes.

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Section B

2 marks each

  1. Q.17 (A)2 marks
    How are morphine and heroin related ? Mention their effect on the human body.
  2. OR

    Q.17 (B)2 marks
    (i) Name an alcoholic drink which is produced by the help of microbes : (1) With distillation (2) Without distillation (ii) Explain how cyanobacteria can be used as bio-fertilizer.
  3. Q.18 (A)2 marks
    Analyse the following ecosystems and discuss, which will be more productive in terms of primary productivity : A young forest, a natural old forest, a shallow polluted lake.
  4. OR

    Q.18 (B)2 marks
    Differentiate between Net primary productivity and Gross primary productivity in an ecosystem.
  5. Q.192 marks
    Study the cross given below : Identify the abnormalities '1' and '2' in the offsprings of a cross done between a couple and distinguish between them.
  6. Q.202 marks
    Study the pedigree chart given below, showing the inheritance pattern of blood group in a family : Answer the following questions : (a) Give the possible genotypes of individual 1 and 2. (b) Which antigen or antigens will be present on the plasma membranes of the R.B.Cs of individuals '5' and '8' ?
  7. Q.21 (A)2 marks
    A patient with ADA deficiency requires periodic infusion of genetically engineered lymphocytes. Explain why such periodic infusion is required and also suggest a permanent cure for such ADA deficiency.
  8. OR

    Q.21 (B)2 marks
    Describe in brief any two techniques that can be utilised to transfer recombinant DNA into the host cell directly without using any vector.

Section C

3 marks each

  1. Q.223 marks
    (a) Write the palindromic nucleotide sequence for following sequence of DNA segment : 5' – GAATTC – 3' (b) Name the restriction endonuclease that recognizes this sequence. (c) How are sticky ends produced ? Mention their role.
  2. Q.233 marks
    Study a part of life cycle of Plasmodium given below : Answer the following questions : (a) Name the infective stage of Plasmodium that is stored in the female Anopheles mosquito. (b) Where does fertilization and development of parasite take place ? (c) Identify labels P and Q in the given diagram. (d) Asexual and sexual phase of the life cycle of the Plasmodium takes place in two different hosts. Write their names.
  3. Q.243 marks
    (a) Indiscriminate human activities such as alien species invasion, fragmentation and habitat loss have accelerated the loss of biodiversity. Justify by taking one example for each. (b) State the importance of the following : (i) IUCN Red data list (ii) Hot spots in conservation of biodiversity
  4. Q.253 marks
    Study the diagram given below and answer the questions that follows : (a) Identify the structure shown in the above figure. (b) Identify the labels P and Q. (c) Write the nature of histone proteins. (d) Distinguish between Euchromatin and Heterochromatin.
  5. Q.263 marks
    Shyam and Radha are expecting their first child with Radha being in her second month of pregnancy with no complications. Shyam's family has a history of cystic fibrosis while Radha's family has a history of Down's syndrome, leading to a concern that the baby may have one of these conditions. (a) Suggest and explain a way of testing if their baby is at risk for any genetic disorders. (b) In case of presence of one or both of the abnormalities and posing a risk to the mother's health, mention one possible option for them to consider. Is that option safe for Radha at the current gestational age ? Justify. (c) Under what conditions is the process mentioned in (b) illegal ?
  6. Q.273 marks
    Explain the basis on which gel electrophoresis technique works. Write any two ways the products obtained through this technique can be utilised.
  7. Q.283 marks
    Compare and contrast convergent and divergent evolution.

Section D

  1. Study the graphs given below for Case 1 and Case 2 showing different levels of certain hormones and answer the question that follows :
    Q.29 (a)1 mark
    Which hormone is responsible for the peak observed in Case 1 and Case 2 ? Write one function of that hormone.
  2. Q.29 (b)2 marks
    Write changes that take place in the ovary and uterus during follicular phase.
  3. Q.29 (c)1 mark
    Name the hormone Q of Case 2. Write one function of hormone Q.
  4. OR

    Q.29 (d)1 mark
    Which structure in the ovary will remain functional in Case 2 ? How is it formed ?
  5. In nature, we rarely find isolated, single individuals of any species; majority of them live in groups in a well-defined geographical area, share or compete for similar resources, potentially interbreed and thus constitute a population. The population has certain attributes whereas, an individual organism does not. A population at a given time is composed of individuals of different ages. The size of the population tells us a lot about its status in the habitat. Whatever ecological processes we wish to investigate in a population, be it the outcome of competition with another species, the impact of the predator or the effect of pesticide application, we always evaluate in terms of any change in the population size. The size, in nature, could be low or go into millions. Population size, technically called population density (N) need not necessarily be measured in numbers only. The size of a population for any species is not a static parameter. It keeps on changing with time depending on various factors including food availability, predation pressure and adverse weather.
    Q.30 (a)1 mark
    The Monarch butterfly is highly distasteful to its predator because of a special chemical present in its body. How does the butterfly acquire this chemical ?
  6. Q.30 (b)2 marks
    If population density at a time t + 1 is 800, Emigration = 100, Immigration = 200, Natality = 200 and Mortality = 150, calculate the population density at time t and comment upon the type of age pyramid that will be formed in this case.
  7. Q.30 (c)1 mark
    What is the difference in a method of measuring population density in an area if there are 200 carrot grass plants to only single huge banyan tree ?
  8. OR

    Q.30 (d)1 mark
    Name two methods to measure the population density of tigers.

Section E

5 marks each

  1. Q.31 (A)5 marks
    Answer the following questions : (i) State what do you understand by "MALT" ? Where it is located inside our body ? (ii) Explain cytokine barriers. (iii) Name the diagnostic test for AIDS. On what principle does it work ? (iv) Bone marrow and thymus play an important role in human immune system. Explain how are they able to achieve this.
  2. OR

    Q.31 (B)5 marks
    (i) Study the following table & fill 'H', 'I', 'J', 'K', 'L' and 'M' in following table with suitable words :
    Chemical / Bioactive MoleculeMicro-organismCategoryUse
    (a)Butyric acidHIImportant applications in food, chemical & pharma industry
    (b)JMonoscus purpureusKInhibit cholesterol biosynthesis pathway
    (c)Cyclosporin ALFungusM
    (ii) Why are baculoviruses used as biological control agents ?
  3. Q.32 (A)5 marks
    (a) Distinguish between the two cells enclosed in a mature male gametophyte of an angiosperm. (b) Study the diagram given below showing the modes of pollination. Answer the questions that follow. (i) The given diagram shows three methods of pollen transfer in plants. Examine them carefully and write the technical terms used for pollen transfer methods '1', '2' and '3'. (ii) How do the following plants achieve pollination successfully ? (a) Water lily (b) Vallisneria (iii) Write advantages of pollen transfer in method '3'.
  4. OR

    Q.32 (B)5 marks
    Given below is the diagram of human ovum surrounded by a few sperms. Observe the diagram and answer the questions that follows : (i) Compare the fate of sperms 'P', 'Q' and 'R' shown in the diagram. (ii) Write the role of Zona pellucida in this process. (iii) Analyse the changes occurring in the ovum after the entry of sperm. (iv) How acrosome and middle piece of a human sperm are able to play an important role in human fertilization ?
  5. Q.33 (A)5 marks
    (i) Perform a cross between two sickle cell carriers. What ratio is obtained between carrier, disease free and diseased individuals in F1\text{F}_1 progeny ? Name the nitrogenous base substituted, in the haemoglobin molecule in this disease. (ii) Explain the difference in inheritance pattern of flower colour in garden pea plant and snap-dragon plant with the help of monohybrid crosses.
  6. OR

    Q.33 (B)5 marks
    Explain with the help of well-labelled diagrams how lac operon operates in E. coli : (i) In presence of an inducer. (ii) In absence of an inducer.